Journal article
Lipidomics reveals a tissue-specific fingerprint
I Pradas, K Huynh, R Cabré, V Ayala, PJ Meikle, M Jové, R Pamplona
Frontiers in Physiology | FRONTIERS MEDIA SA | Published : 2018
Open access
Abstract
In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and organelles, as well as in tissues, whose lipid distribution remains unclear. Here, we report a mass spectrometry study of lipid abundance across 7 rat tissues, detecting and quantifying 652 lipid molecular species from the glycerolipid, glycerophospholipid, fatty acyl, sphingolipid, sterol lipid and prenol lipid categories. Our results demonstrate that every tissue analyzed presents a specific lipid distribution and concentration. Thus, glycerophospholipids are the most abun..
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Awarded by Spanish Ministry of Economy and Competitiveness
Awarded by Autonomous Government of Catalonia
Funding Acknowledgements
We acknowledge funding from the Spanish Ministry of Economy and Competitiveness (ref. PI1400328), and the Autonomous Government of Catalonia (ref. 2017SGR696) to RP. This study has been co-financed by FEDER funds from the European Union (Una manera de hacer Europa). IP was supported by a University of Lleida Predoctoral Fellowship. RC was supported by a Generalitat of Catalonia Predoctoral Fellowship.