Journal article
Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children
L Hjort, D Martino, LG Grunnet, H Naeem, J Maksimovic, AH Olsson, C Zhang, C Ling, SF Olsen, R Saffery, AA Vaag
Jci Insight | AMER SOC CLINICAL INVESTIGATION INC | Published : 2018
Open access
Abstract
Offspring of women with gestational diabetes mellitus (GDM) are at increased risk of developing metabolic disease, potentially mediated by epigenetic mechanisms. We recruited 608 GDM and 626 control offspring from the Danish National Birth Cohort, aged between 9 and 16 years. DNA methylation profiles were measured in peripheral blood of 93 GDM offspring and 95 controls using the Illumina HumanMethylation450 BeadChip. Pyrosequencing was performed for validation/replication of putative GDM-associated, differentially methylated CpGs in additional 905 offspring (462 GDM, 444 control offspring). We identified 76 differentially methylated CpGs in GDM offspring compared with controls in the discove..
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Awarded by Innovation Fund Denmark
Awarded by Academy of Finland (AKA)
Funding Acknowledgements
We greatly appreciate all the children and their mothers who participated in the study. Additional DNBC GDM study team members include Freja Bach Kampmann, Anne-Cathrine Baun Thuesen, Malan Egholm, Camilla Moller Madsen, Cecilie Fau Brinklov, and all student assistants, who did a tremendous work assisting in collecting in vivo data. Also, we want to acknowledge the collaboration with Staten's Serum Institute DNBC study members Susanne Hansen, Anne Ahrendt, Marin Strom, Charlotta Granstrom, and Kenneth Agerskov in the organization of the GDM study. We thank the clinics across Denmark for providing housing facilities for the clinical study. This study was funded by the Danish Council for Strategic Research, The Innovation Fund Denmark (09-067124 and 11-115923), Rigshospitalet/The Copenhagen University Hospital, The faculty of Health and Medical Sciences, Copenhagen University, and the Danish Diabetes Academy supported by the Novo Nordisk Foundation.