Journal article

Optimal Delay Time of CT Perfusion for Predicting Cerebral Parenchymal Hematoma After Intra-Arterial tPA Treatment

Bing Wu, Nan Liu, Max Wintermark, Mark W Parsons, Hui Chen, Longting Lin, Shuai Zhou, Gang Hui, Yongwei Zhang, Jun Hui, Ying Li, Zihua Su, Xinhuai Wu, Guangming Zhu

Frontiers in Neurology | FRONTIERS MEDIA SA | Published : 2018

Abstract

Background and Purpose: Cerebral hemorrhage is a serious potential complication of stroke revascularization, especially in patients receiving intra-arterial tissue-type plasminogen activator (tPA) therapy. We investigated the optimal pre-intervention delay time (DT) of computed tomography perfusion (CTP) measurement to predict cerebral parenchymal hematoma (PH) in acute ischemic stroke (AIS) patients after intra-arterial tissue plasminogen activator (tPA) treatment. Methods: The study population consisted of a series of patients with AIS who received intra-arterial tPA treatment and had CTP and follow-up computed tomography/magnetic resonance imaging (CT/MRI) to identify hemorrhagic transfor..

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Grants

Awarded by National Natural Science Foundations of China


Funding Acknowledgements

The National Natural Science Foundations of China (Grant No. 81371286, No. 81501024, No. 81601035, and No. 81771273) and Science Cooperative Foundation of China and Hungary (HCSCF-2016-2) supported this study.