Journal article

The presence of Interleukin-13 in nasal lavage may be a predictor of nasal polyposis in pediatric patients with cystic fibrosis

Jamil Manji, Andrew Thamboo, Mark Tacey, Cathie Garnis, Neil K Chadha



BACKGROUND: Sinonasal disease is a common feature of cystic fibrosis (CF) and can cause significant morbidity in these patients. Our objective was to determine if CF individuals with concomitant nasal polyposis (NP) express a unique profile of inflammation and if so, whether these inflammatory cytokine mediators have predictive value in identifying these individuals for prompt management by an Otolaryngologist. METHODOLOGY: Nasal lavage samples and clinical outcomes of disease severity were obtained from thirty-eight pediatric CF individuals. Participants were subdivided based on the presence or absence of NP. Nasal lavage samples were analyzed on a panel of seventeen cytokine targets using ..

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Funding Acknowledgements

We gratefully acknowledge the contributions of our Research Coordinators, Rachelle Dar Santos and Julie Pauwels, in seeing this project to completion; and BC Children's Hospital pediatric cystic fibrosis clinic for accommodating our study during clinic hours. None of these individuals received compensation for their contributions. External funding was provided by the Rare Diseases Foundation and the Child and Family Research Institute Innovations in Acute Care & Technology (iACT) grant.