Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington's disease
Geraldine Kong, Le Cao Kim-Anh, Louise M Judd, ShanShan Li, Thibault Renoir, Anthony J Hannan
NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a trinucleotide repeat expansion in the huntingtin (HTT) gene, which is expressed ubiquitously throughout the brain and peripheral tissues. Whilst the focus of much research has been on the cognitive, psychiatric and motor symptoms of HD, the extent of peripheral pathology and its potential impact on central symptoms has been less intensely explored. Disruption of the gastrointestinal microbiome (gut dysbiosis) has been recently reported in a number of neurological and psychiatric disorders, and therefore we hypothesized that it might also occur in HD. We have used 16S rRNA amplicon sequencing to characterize the..View full abstract
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This research was supported by the NHMRC. KALC is an NHMRC Career Development Fellow (GNT1087415). TR is an NHMRC-ARC Dementia Fellow (GNT1136529). AJH is an NHMRC Principal Research Fellow (GNT1117148) and is also supported by the DHB Foundation, Equity Trustees.