Journal article

Converse Smith-Martin cell cycle kinetics by transformed B lymphocytes

K Pham, A Kan, L Whitehead, RJ Hennessy, K Rogers, PD Hodgkin

CELL CYCLE | TAYLOR & FRANCIS INC | Published : 2018

Abstract

Recent studies using direct live cell imaging have reported that individual B lymphocytes have correlated transit times between their G1 and S/G2/M phases. This finding is in contradiction with the influential model of Smith and Martin that assumed the bulk of the total cell cycle time variation arises in the G1 phase of the cell cycle with little contributed by the S/G2/M phase. Here we extend these studies to examine the relation between cell cycle phase lengths in two B lymphoma cell lines. We report that transformed B lymphoma cells undergo a short G1 period that displays little correlation with the time taken for the subsequent S/G2/M phase. Consequently, the bulk of the variation noted..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Human Frontiers Science Program


Awarded by Australian Government National Health and Medical Research Council Independent Research Institutes Infrastructure Support Scheme


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (NH&MRC) via Project Grant 1057831 and Program Grant 1054925; Human Frontiers Science Program RGP0060/2012; the Australian Government National Health and Medical Research Council Independent Research Institutes Infrastructure Support Scheme Grant 361646; and an NH& MRC fellowship to P.D.H.