Journal article
Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets
YK Tham, BC Bernardo, K Huynh, JYY Ooi, XM Gao, H Kiriazis, C Giles, PJ Meikle, JR McMullen
Cell Reports | CELL PRESS | Published : 2018
Abstract
Exercise-induced heart growth provides protection against cardiovascular disease, whereas disease-induced heart growth leads to heart failure. These distinct forms of growth are associated with different molecular profiles (e.g., mRNAs, non-coding RNAs, and proteins), and targeting differentially regulated genes has therapeutic potential for heart failure. The effects of exercise on the cardiac and circulating lipidomes in comparison to disease are unclear. Lipidomic profiling was performed on hearts and plasma of mice subjected to swim endurance training or a cardiac disease model (moderate or severe pressure overload). Several sphingolipid species and phospholipids containing omega-3/6 fat..
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Awarded by Dementia Australia Research Foundation
Funding Acknowledgements
This study was funded by a National Health and Medical Research Council project grant (APP1045585 to J.R.M.), funding from the Borella family and Reece Borella Medal Presentation Night, and also supported in part by the Victorian Government's Operational Infrastructure Support Program. P.J.M. and J.R.M. are National Health and Medical Research Council Senior Research Fellows (IDs 1042095, 586604, and 1078985). J.R.M. was also supported by an Australian Research Council Future Fellowship (FT0001657). K.H. was supported jointly by an Alzheimer's Australia Dementia Research Foundation Scholarship and Baker Heart and Diabetes Institute Postgraduate Scholarship. Y.K.T. was supported by an Australian Postgraduate Award and Baker Heart and Diabetes Institute Top up Stipend. We wish to thank X.J. Du for assistance with the TAC surgeries; N. Cemerlang, A. Matsumoto, and L. Lim for assistance with animal procedures; and N.A. Mellett for technical assistance with the mass spectrometer.