Journal article

BIG Regulates Dynamic Adjustment of Circadian Period in Arabidopsis thaliana

Timothy J Hearn, Maria C Marti Ruiz, SM Abdul-Awal, Rinukshi Wimalasekera, Camilla R Stanton, Michael J Haydon, Frederica L Theodoulou, Matthew A Hannah, Alex AR Webb



Circadian clocks drive rhythms with a period near 24 h, but the molecular basis of the regulation of the period of the circadian clockis poorly understood. We previously demonstrated that metabolites affect the free-running period of the circadian oscillator of Arabidopsis (Arabidopsis thaliana), with endogenous sugars acting as an accelerator and exogenous nicotinamide acting as a brake. Changes in circadian oscillator period are thought to adjust the timing of biological activities through the process of entrainment, in which the circadian oscillator becomes synchronized to rhythmic signals such as light and dark cycles as well as changes in internal metabolism. To identify the molecular c..

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University of Melbourne Researchers


Awarded by Biotechnology and Biological Sciences Research Council (BBSRC) CASE studentship - Bayer Cropscience

Awarded by BBSRC

Funding Acknowledgements

T.J.H. was supported by Biotechnology and Biological Sciences Research Council (BBSRC) CASE studentship 1090203 supported by Bayer Cropscience and BBSRC Grant BB/M006212/1. M.C.M. was supported by a University of Cambridge Broodbank Fellowship.