Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Yutian Ma; Mattias Bjoernmalm; Andrew K Wise; Christina Cortez-Jugo; Eve Revalor; Yi Ju; Orlagh M Feeney; Rachael T Richardson; Eric Hanssen; Robert K Shepherd; Christopher JH Porter; Frank Caruso

Journal article

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso

ACS APPLIED MATERIALS & INTERFACES | AMER CHEMICAL SOC | Published : 2018

DOI: 10.1021/acsami.8b10415

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Abstract

Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release of therapeutics in biomedical applications. However, current synthesis methods used to achieve high drug loading and those involving biocompatible materials are often tedious and low throughput, thereby limiting the translation of SPs to diverse applications. Herein, we present a simple, effective, and automatable alginate-mediated electrospray technique for the assembly of robust spherical silica SPs (Si-SPs) for long-term (>4 months) drug delivery. The Si-SPs are composed of either porous or nonporous primary Si particles within a decomposable alginate matrix. The size and ..

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University of Melbourne Researchers

Robert Shepherd Author Medical Bionics Department

Christina Cortez-Jugo Author Chemical Engineering

Andrew Wise Author Medical Bionics Department

Frank Caruso Author Chemical Engineering

Rachael Richardson Author Medical Bionics Department

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Grants

Awarded by Australian Research Council Centre of Excellence in Convergent BioNano Science and Technology

Awarded by Australian National Health and Medical Research Council

Awarded by National Health and Medical Research Council

Awarded by European Union

Funding Acknowledgements

This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent BioNano Science and Technology (project number CE140100036), the Australian National Health and Medical Research Council Project Grants GNT1064375 and GNT1142910, and the Robert Bulley Foundation. F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (APP1135806). The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. M.B. acknowledges support from Horizon 2020 (European Union) through a Marie Sklodowska-Curie Individual Fellowship (grant agreement no. 745676). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). We also thank Paul Brannon for assistance with preparing Figure 5, Dr. Ranjeet Singh for running N<INF>2</INF> sorption analyses to measure the pore size distribution using a Micrometrics ASAP2010 analyzer, Dr. Alex Duan for XPS assistance, and Dr. Joseph J. Richardson, Dr. Jianhua Li, Dr. Quinn Besford, and Zhixing Lin for helpful discussions.