Revealing the protective and pathogenic potential of MAIT cells
Criselle D'Souza, Zhenjun Chen, Alexandra J Corbett
MOLECULAR IMMUNOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018
Mucosal-associated Invariant T (MAIT) cells represent a large proportion of T cells in human blood, and are also present throughout the body, being concentrated at mucosal sites. Their high level of conservation throughout mammalian evolution and recognition of conserved microbial antigens, derived from precursors of riboflavin (vitamin B2) biosynthesis, suggest an important role in protective immunity to pathogens. However, the picture that is emerging of MAIT cell immune function is increasingly complex, with numerous correlations of MAIT cell numbers with human diseases, and with recent studies demonstrating their pathogenic potential. The conditions that drive MAIT cell responses towards..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council
ZC and AC are inventors on patents describing MR1 tetramers. The authors have no other competing interests. This work was supported by National Health and Medical Research Council of Australia, Program Grant 1113293 Grant 1113293. AC is supported by a Future Fellowship from the Australian Research Council FT160100083.