Journal article

Magnesium sulfate therapy after cardiac surgery: a before-and-after study comparing strategies involving bolus and continuous infusion

Eduardo Osawa, Peter Biesenbach, Salvatore L Cutuli, Glenn M Eastwood, Johan Martensson, George Matalanis, Jessica Fairley, Rinaldo Bellomo

CRITICAL CARE AND RESUSCITATION | AUSTRALASIAN MED PUBL CO LTD | Published : 2018

Abstract

BACKGROUND: Magnesium therapy may reduce the risk of atrial fibrillation after cardiac surgery. However, studies are heterogeneous in relation to dosage and method of delivery and no studies have directly compared the biochemical effect of different delivery strategies. AIMS: We conducted a before-and-after study to compare the effects of two strategies of magnesium delivery after cardiac surgery. METHODS: We conducted a prospective interventional before-and-after study. We enrolled patients admitted to the intensive care unit (ICU) after cardiac surgery and with no history of renal failure. The before period consisted of a single 20 mmol of magnesium sulfate bolus administered over one hour..

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