Characterizing the functional connectivity diversity of the insula cortex: Subregions, diversity curves and behavior
Ye Tian, Andrew Zalesky
NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2018
The connectivity of the insula cortex is diverse. We present new models to characterize the resting-state connectional diversity of the human insula cortex and perform model selection using high-quality fMRI data from the Human Connectome Project. We first attempt to parcellate the insula into distinct subregions using traditional clustering methods, but find that the resulting subregions are not homogeneous and that the optimal number of subregions is substantially influenced by data smoothness. We then introduce the concept of a diversity curve, which we use to continuously parameterize the insula's Laplacian eigenmap with respect to streamlines propagated through the eigenmap's gradient f..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Y.T. was supported by the China Scholarship Council - University of Melbourne Research Scholarship. A.Z. was supported by the Australian National Health and Medical Research Council (NHMRC) Senior Research Fellowship B (ID: 1136649).