Journal article

The Genetic Landscape and Clonal Evolution of Breast Cancer Resistance to Palbociclib plus Fulvestrant in the PALOMA-3 Trial

Ben O'Leary, Rosalind J Cutts, Yuan Liu, Sarah Hrebien, Xin Huang, Kerry Fenwick, Fabrice Andre, Sibylle Loibl, Sherene Loi, Isaac Garcia-Murillas, Massimo Cristofanilli, Cynthia Huang Bartlett, Nicholas C Turner

Cancer Discovery | AMER ASSOC CANCER RESEARCH | Published : 2018


Awarded by Medical Research Council

Awarded by Cancer Research UK

Funding Acknowledgements

We thank the patients, families, and trial staff who took part in the PALOMA-3 trial. We thank Francesca Demichelis and Alessandro Romanel for their help in performing the CLONET validation analyses, Irene Chong for assistance with MYC amplification validation by digital PCR, and Erle Holgersen for advice regarding the circos plots. This research was funded by The Medical Research Council (MR/N002121/1) and Breast Cancer Now with support from the Mary-Jean Mitchell Green Foundation and Pfizer. ICR-CTSU receives program grant funding from Cancer Research UK (grant C1491/A15955). We acknowledge National Institute for Health Research funding to the Royal Marsden and Institute of Cancer Research Biomedical Research Centre.