Journal article

The relationship between depression and cognitive function in adults with cardiovascular risk: Evidence from a randomised attention-controlled trial

Haley M LaMonica, Daniel J Biddle, Sharon L Naismith, Ian B Hickie, Paul Maruff, Nicholas Glozier

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2018


BACKGROUND AND AIM: This study assessed the association between depressive symptom severity and cognition in middle-to-older aged adults with mild-to-moderate depression and cardiovascular risk factors using an online test battery (CogState) and whether changes in depressive symptoms over 3 months were associated with changes in cognition. METHODS: Participants (mean age = 57.8) with cardiovascular risk and mild-to-moderate depressive symptoms completed measures of psychomotor speed, learning, and executive function prior to (n = 445)_and after (n = 334) online depression or attention control interventions. The symptom severity-cognition relationship was examined both cross-sectionally and p..

View full abstract

University of Melbourne Researchers


Awarded by Cardiovascular Disease and Depression Strategic Research Program - National Heart Foundation of Australia

Funding Acknowledgements

The trial was supported by the Cardiovascular Disease and Depression Strategic Research Program (Award Reference No. G08S 4048 to I.H.) funded by the National Heart Foundation of Australia and beyondblue: the national depression initiative. The 45 and Up Study is managed by The Sax Institute in collaboration with major partner Cancer Council New South Wales; and partners the National Heart Foundation of Australia (NSW Division); NSW Health; beyondblue: the national depression initiative; Ageing, Disability and Home Care, Department of Human Services NSW; and UnitingCare Ageing.