Journal article

The TAM receptor TYRO3 is a critical regulator of myelin thickness in the central nervous system

Farrah Blades, Andrea Aprico, Rainer Akkermann, Sarah Ellis, Michele D Binder, Trevor J Kilpatrick

GLIA | WILEY | Published : 2018

Abstract

Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system (CNS). Major deficits arise in MS patients due to an inability to repair damaged myelin sheaths following CNS insult, resulting in prolonged axonal exposure and neurodegeneration. The TAM receptors (Tyro3, Axl, and Mertk) have been implicated in MS susceptibility, demyelination and remyelination. Previously, we have shown that Tyro3 regulates developmental myelination and myelin thickness within the optic nerve and rostral region of the corpus callosum (CC) of adult mice. In this study we have verified and extended our previous findings via a comprehensive analysis of axonal ensheathment and myelin ..

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