Journal article

Extending Antenatal Pertussis Immunization to Second Trimester or At-Birth Pertussis Immunization of Premature Infants? Reply

Nicholas Wood, Terry Nolan, Peter McIntyre

JAMA PEDIATRICS | AMER MEDICAL ASSOC | Published : 2019

Abstract

Importance: An alternative option to maternal vaccination to prevent severe pertussis in infants is vaccination at birth. Data are needed on the immunogenicity and safety of a birth dose of monovalent acellular pertussis (aP) vaccine. Objective: To compare IgG antibody responses to vaccine antigens at 6, 10, 24, and 32 weeks of age between newborn infants receiving the aP vaccine and hepatitis B vaccine (HBV) or HBV alone. Design, Setting, and Participants: A randomized clinical trial was conducted at 4 sites in Australia (Sydney, Melbourne, Adelaide, and Perth) between June 11, 2010, and March 14, 2013, among 440 healthy term (>36 weeks' gestation) infants aged less than 5 days at recruitme..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC


Awarded by Australian NHMRC project


Funding Acknowledgements

Drs Wood and Marshall are supported by National Health and Medical Research Council (NHMRC) Career Development Fellowships APP1063629 (Dr Wood) and APP1084951 (Dr Marshall). Dr Perrett was supported by an NHMRC Early Career Fellowship (APP1054394) and a Murdoch Children's Research Institute Career Development Award. This study was supported by Australian NHMRC project grant 570756.