Journal article

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

Hazel Tye, Chien-Hsiung Yu, Lisa A Simms, Marcel R de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S Penington, Cassandra R Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F Wockner, Adele Preaudet, Lisa A Mielke, Stephen A Wilcox, Yasunori Ogura, Sinead C Corr, Komal Kanojia, Konstantinos A Kouremenos, David P De Souza, Malcolm J McConville, Richard A Flavell Show all

Nature Communications | NATURE PUBLISHING GROUP | Published : 2018

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by Independent Research Institutes Infrastructure Support Scheme Grant


Funding Acknowledgements

We thank L. Cengia and R. Lane for excellent technical assistance, and L. Scott, C. Hay and R. Crawley for outstanding animal husbandry. This work was supported by: Australian National Health and Medical Research Council (NHMRC) Project Grants (1057815, 1099262), Program Grants (461219, 1054618), fellowships (to B.T.K., S.L.M., M.J.M.) and an Independent Research Institutes Infrastructure Support Scheme Grant (361646). Fellowships from the Victorian Endowment for Science Knowledge and Innovation (to S.L.M.), HHMI-Wellcome International Research Scholarship (to S.L.M.), the Australian Research Council (to B.T.K.), the Sylvia and Charles Viertel Foundation (to B.T.K. and S.L.M.), the WEHI Centenary Fellowship (to C.-H.Y.) and Ormond College's Thwaites Gutch Fellowship in Physiology (to C.-H.Y.), the WEHI Centenary Dyson Bequest (to T.L.P.), and the Victorian Cancer Agency (to T.L.P.); the Australian Cancer Research Fund, the Australian Phenomics Network, the Ian Potter Centre for Genomics and Personalized Medicine and a Victorian State Government Operational Infrastructure Support Grant. The human microarray work was supported by a research grant from Amgen (South San Francisco, CA 94080). S.L.M. receives funding from Glaxosmithkline.