Journal article

Salivary C-reactive protein among at-risk adolescents: A methods investigation of out of range immunoassay data

ER Landau, J Trinder, JG Simmons, M Raniti, M Blake, JM Waloszek, L Blake, O Schwartz, G Murray, NB Allen, ML Byrne

PSYCHONEUROENDOCRINOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019

Abstract

Inflammatory markers including C-Reactive Protein (CRP) are increasingly used within research and clinical settings. Yet, varying methodologies for cleaning immunoassay data with out of range (OOR) samples may alter characteristic levels of CRP, thereby obscuring interpretation and reliability. This study investigated the influence of eight immunoassay OOR data treatment techniques on salivary CRP (sCRP) samples from at-risk adolescents. Participants from the 'Sleep and Education: learning New Skills Early' (SENSE) Study were 86 adolescents at-risk for depression (50 female), aged 14.29 years (SD = 1.04). ANOVA results showed no statistically significant differences in average morning (F(7, ..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by National Institute of Mental Health (NIMH)


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

The authors received funding from the Australian National Health and Medical Research Council Grant (APP1027076) for this study. Dr. Byrne is supported by a National Institute of Mental Health (NIMH) K01 Award (K01MH111951). The authors would also like to thank the participants of the SENSE Study and the following individuals for their contribution to the project: Camille Dean, Stefanie Rosema, Viviana Lee, Jess Slonim, Michael Gate, Vanessa Rowell, Tamsen Franklin, Stefan Friedel, Lauren Ban, Lian Snoep, Natasa Stoilov, Anja Plagemann, Giovanni Andreoli, Alex Klein, Carra Simpson, Michael Wilson, and Adam Pettitt.