Ceruloplasmin Is a Novel Adipokine Which Is Overexpressed in Adipose Tissue of Obese Subjects and in Obesity-Associated Cancer Cells
Erik Arner, Alistair RR Forrest, Anna Ehrlund, Niklas Mejhert, Masayoshi Itoh, Hideya Kawaji, Timo Lassmann, Jurga Laurencikiene, Mikael Ryden, Peter Arner
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2014
Obesity confers an increased risk of developing specific cancer forms. Although the mechanisms are unclear, increased fat cell secretion of specific proteins (adipokines) may promote/facilitate development of malignant tumors in obesity via cross-talk between adipose tissue(s) and the tissues prone to develop cancer among obese. We searched for novel adipokines that were overexpressed in adipose tissue of obese subjects as well as in tumor cells derived from cancers commonly associated with obesity. For this purpose expression data from human adipose tissue of obese and non-obese as well as from a large panel of human cancer cell lines and corresponding primary cells and tissues were explore..View full abstract
Awarded by Novo Nordisk Fonden
Awarded by NATIONAL CANCER INSTITUTE
FANTOM5 was made possible by a Research Grant for RIKEN Omics Science Center from MEXT to Yoshihide Hayashizaki and a Grant of the Research Program of Innovative Cell Biology by Innovative Technology (Cell Innovation Program) from MEXT, Japan to Yoshihide Hayashizaki. This study was also supported by grants from the Swedish Research Council and the Swedish Cancer Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.