Journal article

An atypical role for the myeloid receptor Mincle in CNS injury

Thiruma Arumugam, Silvia Manzanero, Milena Furtado, Patrick Biggins, Yu-Hsuan Hsieh, Mathias Gelderblom, Kelli PA MacDonald, Ekaterina Salimova, Yu-I Li, Othmar Korn, Deborah Dewar, Mhairi Macrae, Robert Ashman, Sung-Chun Tang, Nadia Rosenthal, Marc Ruitenberg, Tim Magnus, Christine Wells

Published : 2016


Abstract Mincle is a C-type lectin known to play a role in innate immune responses to sterile inflammation, but its contribution to pathologies following an ischemic or traumatic injury is not well understood. In the current study we demonstrate a key role for Mincle in ischemic (i.e. transient middle cerebral artery occlusion) but not traumatic central nervous system injury; absence of Mincle also did not significantly alter the extent of tissue damage or functional outcome in peripheral models of ischemic tissue injury. In the stroke model mice lacking Mincle displayed significantly improved functional outcome from focal cerebral ischemia. The functional improvements in Mincle KO animals w..

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University of Melbourne Researchers