Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

Donia M Moujalled; Giovanna Pomilio; Corina Ghiurau; Adam Ivey; Jessica Salmon; Sewa Rijal; Sarah Macraild; Lan Zhang; Tse-Chieh Teh; Ing-Soo Tiong; Ping Lan; Maia Chanrion; Audrey Claperon; Francesca Rocchetti; Adrien Zichi; Laurence Kraus-Berthier; Youzhen Wang; Ensar Hamovic; Erick Morris; Frederic Colland; David Segal; David Huang; Andrew W Roberts; Ana Leticia Maragno; Guillaume Lessene; Olivier Geneste; Andrew H Wei

Journal article

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

Donia M Moujalled, Giovanna Pomilio, Corina Ghiurau, Adam Ivey, Jessica Salmon, Sewa Rijal, Sarah Macraild, Lan Zhang, Tse-Chieh Teh, Ing-Soo Tiong, Ping Lan, Maia Chanrion, Audrey Claperon, Francesca Rocchetti, Adrien Zichi, Laurence Kraus-Berthier, Youzhen Wang, Ensar Hamovic, Erick Morris, Frederic Colland Show all

Leukemia | NATURE PUBLISHING GROUP | Published : 2019

DOI: 10.1038/s41375-018-0261-3

University of Melbourne Researchers

Guillaume Lessene Author Medical Biology (W.E.H.I.)

David Huang Author Medical Biology (W.E.H.I.)

David Segal Author Medical Biology (W.E.H.I.)

Andrew Roberts Author

Grants

Funding Acknowledgements

We acknowledge research funding from National Health and Medical Research Council, Victorian Cancer Agency, Leukaemia Foundation of Australia, Leukemia and Lymphoma Society, Australian Cancer Research Foundation, Monash Partners, the Alfred Foundation and the Medical Research Future Fund. This work has received funding support from Servier.