Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression
Dilys Lam, Marie-Laure Ancelin, Karen Ritchie, Rosanne Freak-Poli, Richard Saffery, Joanne Ryan
BMC Psychiatry | BMC | Published : 2018
BACKGROUND: Disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (SLC6A4), responsible for serotonin re-uptake, has received much attention in this regard. Most studies have focused on the polymorphic 5-HTTLPR upstream repeat, or DNA methylation at the promoter CpG island. Few studies have explored the influence of genetic variation across the gene on DNA methylation, and their combined association with depression risk. The aim of this study was to determine whether genetic variation in the SLC6A4 gene influences promoter DNA methylation, and whether these are associated with depression status. METHOD: The ESPRIT study involves a co..View full abstract
Awarded by Agence Nationale de la Recherche Project
Awarded by National Health and Medical Research Council
The ESPRIT project is financed by the regional government of Languedoc-Roussillon, the Agence Nationale de la Recherche Project 07 LVIE 004, and an unconditional grant from Norvartis. This work was also supported by the National Health and Medical Research Council, through a Senior Research Fellowship (APP1045161 to RS); the Murdoch Children's Research Institute (studentship to DL) and the Victorian Government's Operational Infrastructure Support Program. The funders had no role in the design and conduct of the study; in data collection, management, analysis or interpretation of the data and were not involved with the writing, preparation, review or approval of the manuscript.