Inhibition of Radiation and Temozolomide-Induced Invadopodia Activity in Glioma Cells Using FDA-Approved Drugs
Clarissa A Whitehead, Hong PT Nguyen, Andrew P Morokoff, Rodney B Luwor, Lucia Paradiso, Andrew H Kaye, Theo Mantamadiotis, Stanley S Stylli
TRANSLATIONAL ONCOLOGY | ELSEVIER SCIENCE INC | Published : 2018
The most common primary central nervous system tumor in adults is the glioblastoma multiforme (GBM). The highly invasive nature of GBM cells is a significant factor resulting in the inevitable tumor recurrence and poor patient prognosis. Tumor cells utilize structures known as invadopodia to faciliate their invasive phenotype. In this study, utilizing an array of techniques, including gelatin matrix degradation assays, we show that GBM cell lines can form functional gelatin matrix degrading invadopodia and secrete matrix metalloproteinase 2 (MMP-2), a known invadopodia-associated matrix-degrading enzyme. Furthermore, these cellular activities were augmented in cells that survived radiotherap..View full abstract
Awarded by Perpetual IMPACT Philanthropy Grant
This work was supported by the following funding sources: Perpetual IMPACT Philanthropy Grant IPAP2017/0766 and The Royal Melbourne Hospital Neuroscience Foundation.