Journal article

Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies

Qing-E Zhang, Fei Wang, Geng Qin, Wei Zheng, Chee H Ng, Gabor S Ungvari, Zhen Yuan, Songli Mei, Gang Wang, Yu-Tao Xiang

International Journal of Biological Sciences | IVYSPRING INT PUBL | Published : 2018

Abstract

Depression is common in patients with irritable bowel syndrome (IBS), but the reported prevalence across different studies is inconsistent. This meta-analysis systematically examined the presence and severity of depressive symptoms in patients with IBS. Two investigators independently performed a literature search. The pooled depressive symptom severity was calculated using a random effects model. Subgroup, sensitivity and meta-regression analyses were conducted to examine the moderating factors of the development of depressive symptoms. Twenty four studies (n=2,837) comparing depressive symptoms between IBS patients (n=1,775) and healthy controls (n=1,062) were identified; 14 (58.3%) studie..

View full abstract

University of Melbourne Researchers

Grants

Awarded by Beijing Municipal Administration of Hospitals Incubating Program


Awarded by Capital City Clinical Practice and Research Funding of Beijing Municipal Science & Technology Commission


Awarded by Clinical Medicine Development Funding of Beijing Municipal Administration of Hospitals


Awarded by Beijing Municipal Administration of Hospital's Ascent Plan


Funding Acknowledgements

The study was supported in part by grants from the Beijing Municipal Administration of Hospitals Incubating Program (code: PX2016016), the Capital City Clinical Practice and Research Funding of Beijing Municipal Science & Technology Commission (Z141107002514033; Z151100004015042), the Clinical Medicine Development Funding of Beijing Municipal Administration of Hospitals (ZYLX201403; ZYLX201607), and the Beijing Municipal Administration of Hospital's Ascent Plan (DFL20151801).