Journal article

The association between urinary Alzheimer-associated neuronal thread protein and cognitive impairment in late-life depression: a controlled pilot study

Qing-E Zhang, Sihai Ling, Peng Li, Saina Zhang, Chee H Ng, Gabor S Ungvari, Liang-Jen Wang, Sheng-Yu Lee, Gang Wang, Yu-Tao Xiang

International Journal of Biological Sciences | IVYSPRING INT PUBL | Published : 2018

Abstract

Accumulation of tau protein is associated with both Alzheimer's disease (AD) and late-life depression (LLD). Alzheimer-associated neuronal thread protein (AD7c-NTP), which is closely linked with the tau protein, is elevated in the cerebrospinal fluid and urine of AD patients. This study examined the association between urinary AD7c-NTP and late-life depression with cognitive impairment. One hundred and thirty-eight subjects were recruited into late-life depression with cognitive impairment (LLD-CI, n=52), late-life depression without cognitive impairment (LLD-NCI, n=29), AD (n=27), and healthy control (HC, n=30) groups. The level of urinary AD7c-NTP was measured using the enzyme-linked immun..

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University of Melbourne Researchers

Grants

Awarded by Beijing Municipal Administration of Hospitals Incubating Program


Awarded by Beijing Municipal Administration of Hospitals' Youth Program


Funding Acknowledgements

The study was supported by the Beijing Municipal Administration of Hospitals Incubating Program (PX2016016) and the Beijing Municipal Administration of Hospitals' Youth Program (QML20171903).