Germline Variation and Breast Cancer Incidence: A Gene-Based Association Study and Whole-Genome Prediction of Early-Onset Breast Cancer

Molly Scannell Bryan; Maria Argos; Irene L Andrulis; John L Hopper; Jenny Chang-Claude; Kathleen E Malone; Esther M John; Marilie D Gammon; Mary B Daly; Mary Beth Terry; Saundra S Buys; Dezheng Huo; Olofunmilayo I Olopade; Jeanine M Genkinger; Alice S Whittemore; Farzana Jasmine; Muhammad G Kibriya; Lin S Chen; Habibul Ahsan

Journal article

Germline Variation and Breast Cancer Incidence: A Gene-Based Association Study and Whole-Genome Prediction of Early-Onset Breast Cancer

Molly Scannell Bryan, Maria Argos, Irene L Andrulis, John L Hopper, Jenny Chang-Claude, Kathleen E Malone, Esther M John, Marilie D Gammon, Mary B Daly, Mary Beth Terry, Saundra S Buys, Dezheng Huo, Olofunmilayo I Olopade, Jeanine M Genkinger, Alice S Whittemore, Farzana Jasmine, Muhammad G Kibriya, Lin S Chen, Habibul Ahsan

Cancer Epidemiology Biomarkers & Prevention | AMER ASSOC CANCER RESEARCH | Published : 2018

DOI: 10.1158/1055-9965.EPI-17-1185

University of Melbourne Researchers

John Hopper Author Melbourne School of Population and Global Health

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Precision Public Health For Major Cancers - Novel Approaches To Building The Genetic, Epigenetic And Lifestyle Knowledge Base For Assessing Risk And Prognosis

The Program of research seeks to increase our understanding of cancer risk. We will use our large collections of population and family-based..

Grants

Awarded by NIH

Awarded by Cancer Research UK

Awarded by European Union

Funding Acknowledgements

This work was supported by the NIH grant numbers to support the BCFR: RC1CA145506 and U01CA122171 (to H. Ahsan and M. Argos); RC1CA145506, R01CA094069, and UM1CA164920 (to I.L. Andrulis); and UO1CA66572 and U19CA148065. L.S. Chen was supported through R01 GM108711. M. Scannell Bryan was supported by NIH grant numbers R25-CA057699 2T32 and CA057699-26. L.S. Chen was supported by R01GM108711. Samples from the CPIC were processed and distributed by the Coriell Institute for Medical Research. The studies included in the meta-analysis were supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the 'Ministere de l'Economie, de la Science et de l'Innovation du Quebec' through Genome Quebec and grant PSR-SIIRI-701, the NIH (U19 CA148065 and X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, and C1287/A10710), and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders for the meta-analysis are listed in Michailidou and colleagues (2017).