Single Nucleotide Polymorphism Genotyping Analysis Shows That Vaccination Can Limit the Number and Diversity of Recombinant Progeny of Infectious Laryngotracheitis Viruses from the United States
Carlos A Loncoman, Carol A Hartley, Mauricio JC Coppo, Glenn F Browning, Gabriela Beltran, Sylva Riblet, Carolina O Freitas, Maricarmen Garcia, Joanne M Devlin
Appl Environ Microbiol | AMER SOC MICROBIOLOGY | Published : 2018
Infectious laryngotracheitis (ILTV; Gallid alphaherpesvirus 1) causes mild to severe respiratory disease in poultry worldwide. Recombination in this virus under natural (field) conditions was first described in 2012 and more recently has been studied under laboratory conditions. Previous studies have revealed that natural recombination is widespread in ILTV and have also demonstrated that recombination between two attenuated ILTV vaccine strains generated highly virulent viruses that produced widespread disease within poultry flocks in Australia. In the United States, natural ILTV recombination has also been detected, but not as frequently as in Australia. To better understand recombination ..View full abstract
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Awarded by Australian Research Council
This work was supported by the Australian Research Council (FT140101287). Carlos A. Loncoman was supported by Becas Chile, CONICYT, Gobierno de Chile.