Changes in Gut Microbiota Prior to Influenza A Virus Infection Do Not Affect Immune Responses in Pups or Juvenile Mice
Eva Fuglsang, Angela Pizzolla, Lukasz Krych, Dennis S Nielsen, Andrew G Brooks, Hanne Frokiaer, Patrick C Reading
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | FRONTIERS MEDIA SA | Published : 2018
Previous studies demonstrated that oral antibiotic (ABX) treatment prior to and during influenza A virus (IAV) infection of adult mice profoundly altered gut microbiota (GM) and was associated with increased susceptibility and impaired immunity to IAV. We examined the impact of ABX during critical times relevant to the establishment of GM in early life (using perinatal treatment of neonates and direct treatment of juvenile mice) and asked whether cessation of ABX treatment in early life had lasting effects on GM composition and anti-IAV immunity. ABX treatment significantly changed GM composition in juvenile mice and in ABX-treated dams. However, if ABX treatment ceased at the time of infect..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by Danish Strategic Research Council (NEOMUNE)
This work was supported by Project Grant APP1044976 from the National Health and Medical Research Council of Australia. The Melbourne World Health Organization Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health. The project was also supported by the Danish Strategic Research Council (NEOMUNE, grant number 12-132401) and the Augustinus Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.