Journal article

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

Jessica L Bridgford, Stanley C Xie, Simon A Cobbold, Charisse Flerida A Pasaje, Susann Herrmann, Tuo Yang, David L Gillett, Lawrence R Dick, Stuart A Ralph, Con Dogovski, Natalie J Spillman, Leann Tilley

NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2018

Grants

Funding Acknowledgements

We thank Dr Paul Gilson, Prof Brendan Crabb and Dr Mauro F. Azevedo, Burnet Institute, for the DD-GFP parasite line. We thank Christian Doerig, Monash University for providing eIK1 and eIK2 genetically disrupted parasites. We thank Prof Greg Blatch and Eva-Rachele Pesce, Victoria University, for providing recombinant PfBiP. We thank Dr Oded Kleifeld, Technion Israel Institute of Technology and Dr Tobias Spielmann, Bernhard Nocht Institute for Tropical Medicine, for reagents and helpful advice. This work was supported by the National Health & Medical Research Council of Australia and the Australia Research Council.