EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia
Clare L Whitehead, Tu'uhevaha J Kaitu'u-Lino, Natalie K Binder, Sally Beard, Natasha De Alwis, Fiona Brownfoot, Stephen Tong, Natalie J Hannan
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH | ELSEVIER SCI LTD | Published : 2018
INTRODUCTION: Preeclampsia is a severe complication of pregnancy, and likely arises from abnormal placental development in early pregnancy. Persistent placental hypoxia is thought to trigger the release of anti-angiogenic factors into the maternal circulation leading to widespread endothelial dysfunction. Epidermal growth factor-like domain 7 (EGFL7) is a secreted angiogenic factor that may play a key role in the disrupted angiogenesis seen in response to placental hypoxia that characterizes preeclampsia. METHODS: Primary trophoblasts were isolated and cultured in both normoxic and hypoxic conditions. Under hypoxia HIF1α was silenced and EGFL7 mRNA expression was assessed. EGFL7 mRNA express..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by NHMRC
National Health and Medical Research Council (NHMRC) of Australia grant (#1061977, #1048707) and salary support from the NHMRC (#1050765, #1062418, #628927) and a University of Melbourne C R Roper Research Fellowship.