Journal article
Caffeine for apnea of prematurity and brain development at 11 years of age
CE Kelly, WL Ooi, JYM Yang, J Chen, C Adamson, KJ Lee, JLY Cheong, PJ Anderson, LW Doyle, DK Thompson
Annals of Clinical and Translational Neurology | Published : 2018
DOI: 10.1002/acn3.628
Abstract
Objective: Caffeine therapy for apnea of prematurity has been reported to improve brain white matter microstructure at term-equivalent age, but its long-term effects are unknown. This study aimed to investigate whether caffeine affects (1) brain structure at 11 years of age, and (2) brain development from term-equivalent age to 11 years of age, compared with placebo. Methods: Preterm infants born ≤1250 g were randomly allocated to caffeine or placebo. Magnetic resonance imaging (MRI) was performed on 70 participants (33 caffeine, 37 placebo) at term-equivalent age and 117 participants (63 caffeine, 54 placebo) at 11 years of age. Global and regional brain volumes and white matter microstruct..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (Project Grants No. 237117 and No. 108706; Program Grant No. 606789; Centre of Research Excellence No. 1060733; Fellowship No. 1081288 to PJA, No. 1127984 to Kit, No. 1141354 to JLYC and No. 1085754 to DKT). This work was also generously supported by The Royal Children's Hospital Foundation (Grant no. RCH1000) devoted to raising funds for research at The Royal Children's Hospital, as well as the Murdoch Children's Research Institute, the Royal Children's Hospital, Department of Paediatrics at The University of Melbourne and the Victorian Government's Operational Infrastructure Support Program