Exploring the moderating effects of dopaminergic polymorphisms and childhood adversity on brain morphology in schizophrenia-spectrum disorders

C Hoffmann; TE Van Rheenen; SG Mancuso; A Zalesky; J Bruggemann; RK Lenroot; S Sundram; CS Weickert; TW Weickert; C Pantelis; V Cropley; CA Bousman

Journal article

Exploring the moderating effects of dopaminergic polymorphisms and childhood adversity on brain morphology in schizophrenia-spectrum disorders

C Hoffmann, TE Van Rheenen, SG Mancuso, A Zalesky, J Bruggemann, RK Lenroot, S Sundram, CS Weickert, TW Weickert, C Pantelis, V Cropley, CA Bousman

Psychiatry Research Neuroimaging | ELSEVIER IRELAND LTD | Published : 2018

DOI: 10.1016/j.pscychresns.2018.09.002

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Abstract

Genetic and environmental etiologies may contribute to schizophrenia and its associated neurobiological profile. We examined the interaction between dopaminergic polymorphisms, childhood adversity and diagnosis (schizophrenia/schizoaffective disorder) on dopamine-related brain structures. Childhood adversity histories and structural MRI data were obtained from 249 (153 schizophrenia/schizoaffective, 96 controls) participants registered in the Australian Schizophrenia Research Bank. Polymorphisms in DRD2 and COMT were genotyped and a dopaminergic risk allelic load (RAL) was calculated. Regression analysis was used to test the main and interaction effects of RAL, childhood adversity and diagno..

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University of Melbourne Researchers

Tamsyn van Rheenen Author

Andrew Zalesky Author

Christos Pantelis Author

Vanessa Cropley Author

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Grants

Awarded by Brain and Behavior Research Foundation

Funding Acknowledgements

Data for this study were provided by the Australian Schizophrenia Research Bank (ASRB), which is supported by the Australian National Health and Medical Research Council (NHMRC) (Enabling Grant No. 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation and the Schizophrenia Research Institute. TVR was supported by an NHMRC Peter Doherty Fellowship (1088785). SS was supported by One-in-Five Association Incorporated. CSW is funded by the NSW Ministry of Health, Office of Health and Medical Research. CSW is a recipient of a NHMRC Senior Principal Research Fellowship (1117079). CP was supported by an NHMRC Senior Principal Research Fellowship (628386, 1105825), and a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (18722). VC was supported by a Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (21660) and a Melbourne Research Fellowship. CAB was supported by an Australian NHMRC Career Development Fellowship (1127700) and Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (20526). None of the Funding Sources played any role in the study design; collection, analysis or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.