Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex
Georgia M Parkin, Madhara Udawela, Andrew Gibbons, Elizabeth Scarr, Brian Dean
JOURNAL OF HUMAN GENETICS | NATURE PUBLISHING GROUP | Published : 2018
Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the O-methylation, and thereby the inactivation, of catechol-containing molecules. In humans, it has been suggested that COMT modulates cognitive ability, possibly by regulating degradation of dopamine in the prefrontal cortex. Hence, it is significant that two COMT SNPs, rs4680 (c.472 G > A, p.Val158Met) and rs4818 (c.408 C > G), have been associated with cognitive ability in humans. We have shown these SNPs to be associated with levels of muscarinic M1 receptor mRNA in human cortex, which is significant as that receptor also regulates cognitive ability. We decided to determine if COMT genotype was associated with varying level..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC; Australia)
This project was supported by the National Health and Medical Research Council (NHMRC; Australia; project grant 566967), the Cooperative Research Centre (CRC) for Mental Health and the Victorian Government's Operational Infrastructure Support Programme. GMP is an awardee of an Australian Government Research Training Program Scholarship.