Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease

Barbara R Cardoso; Blaine R Roberts; Charles B Malpas; Lucy Vivash; Sila Genc; Michael M Saling; Patricia Desmond; Christopher Steward; Rodney J Hicks; Jason Callahan; Amy Brodtmann; Steven Collins; Stephen Macfarlane; Niall M Corcoran; Christopher M Hovens; Dennis Velakoulis; Terence J O'Brien; Dominic J Hare; Ashley I Bush

Journal article

Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease

Barbara R Cardoso, Blaine R Roberts, Charles B Malpas, Lucy Vivash, Sila Genc, Michael M Saling, Patricia Desmond, Christopher Steward, Rodney J Hicks, Jason Callahan, Amy Brodtmann, Steven Collins, Stephen Macfarlane, Niall M Corcoran, Christopher M Hovens, Dennis Velakoulis, Terence J O'Brien, Dominic J Hare, Ashley I Bush

NEUROTHERAPEUTICS | SPRINGER | Published : 2019

DOI: 10.1007/s13311-018-0662-z

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Abstract

Insufficient supply of selenium to antioxidant enzymes in the brain may contribute to Alzheimer's disease (AD) pathophysiology; therefore, oral supplementation may potentially slow neurodegeneration. We examined selenium and selenoproteins in serum and cerebrospinal fluid (CSF) from a dual-dose 24-week randomized controlled trial of sodium selenate in AD patients, to assess tolerability, and efficacy of selenate in modulating selenium concentration in the central nervous system (CNS). A pilot study of 40 AD cases was randomized to placebo, nutritional (0.32 mg sodium selenate, 3 times daily), or supranutritional (10 mg, 3 times daily) groups. We measured total selenium, selenoproteins, and i..

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University of Melbourne Researchers

Christopher Hovens Author Surgery - Royal Melbourne Hospital

Amy Brodtmann Author Medicine - Austin Health

Ashley Bush Author Florey Department of Neuroscience and Mental Health

Terry O'Brien Author Medicine - Royal Melbourne Hospital

Chris Steward Author Radiology

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Grants

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

Funded by Fellowships from the Brazilian Government Science Without Borders program (Ciencia sem Fronteiras; BRC), Deakin University (BRC), and the Australian National Health and Medical Research Council (GNT1138673, BRR; GNT1105784, SC; GNT1122981, DJH; GNT1103703, AIB); a Program Grant from the Australian National Health and Medical Research Council (GNT1132604, AIB); and by Velacor Therapeutics. Agilent Technologies provided material and research support (BRR, DJH).