Altered in utero kidney development in newborns with congenital heart disease
Gemma B Scholes, Diana Zannino, Joshua Y Kausman, Michael MH Cheung
Pediatric Research | NATURE PUBLISHING GROUP | Published : 2019
BACKGROUND: It is known that the heart is not the only organ affected in congenital heart disease (CHD); there is growth restriction of both the brain and the whole body. The protective mechanism of "the brain-sparing phenomenon" re-directs blood flow toward the growing brain in fetuses with CHD. We hypothesized that these changes would result in impaired fetal kidney growth. METHODS: The preoperative ultrasound measurements of kidney length were obtained retrospectively from 452 neonates requiring surgery for CHD. Percentiles were generated based on regression analysis of normative kidney length from three datasets according to both corrected gestational age and to birthweight. RESULTS: As ..View full abstract
The Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The Heart Research Group is supported by Big W and RCH 1000 of the Royal Children's Hospital Foundation.