Journal article
Treatable traits can be identified in a severe asthma registry and predict future exacerbations
VM McDonald, SA Hiles, K Godbout, ES Harvey, GB Marks, M Hew, M Peters, PG Bardin, PN Reynolds, JW Upham, M Baraket, Z Bhikoo, J Bowden, B Brockway, LP Chung, B Cochrane, G Foxley, J Garrett, L Jayaram, C Jenkins Show all
Respirology | WILEY | Published : 2019
DOI: 10.1111/resp.13389
Abstract
Background and objective: A new taxonomic and management approach, termed treatable traits, has been proposed for airway diseases including severe asthma. This study examined whether treatable traits could be identified using registry data and whether particular treatable traits were associated with future exacerbation risk. Methods: The Australasian Severe Asthma Web-Based Database (SAWD) enrolled 434 participants with severe asthma and a comparison group of 102 participants with non-severe asthma. Published treatable traits were mapped to registry data fields and their prevalence was described. Participants were characterized at baseline and every 6 months for 24 months. Results: In SAWD, ..
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Funding Acknowledgements
This study was funded through grants from AstraZeneca, GlaxoSmithKline, Novartis, Boehringer Ingelheim and Roche. None of these companies had any involvement in the data analysis or manuscript preparation. Individual author disclosures are presented in Appendix S2 (Supplementary Information). This research was previously presented at the Annual Thoracic Society of Australia and New Zealand (TSANZ) 2018.