A versatile quantitative microdroplet elemental imaging method optimised for integration in biochemical workflows for low-volume samples
Kai Kysenius, Bence Paul, James B Hilton, Jeffrey R Liddell, Dominic J Hare, Peter J Crouch
ANALYTICAL AND BIOANALYTICAL CHEMISTRY | SPRINGER HEIDELBERG | Published : 2019
Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) analysis of μ-droplets is becoming an attractive alternative for detecting and quantifying elements in biological samples. With minimal sample preparation required and detection limits comparable to solution nebulisation ICP-MS, μ-droplets have substantial advantages over traditional elemental detection, particularly for low volumes, such as aliquots taken from samples required for multiple independent biochemical assays, or fluids and tissues where elements of interest exist at native concentrations not suited to the necessary dilution steps required for solution nebulisation ICP-MS. However, the characteristics of μ-dr..View full abstract
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This study received support from the Jenny Barr Smith, Betty Laidlaw, and Jenny Simko Research Grants from the MND Research Institute of Australia.