Journal article

Multimodal Structural Neuroimaging Markers of Brain Development and ADHD Symptoms

Gareth Ball, Charles B Malpas, Sila Genc, Daryl Efron, Emma Sciberras, Vicki Anderson, Jan M Nicholson, Timothy J Silk

AMERICAN JOURNAL OF PSYCHIATRY | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2019

Abstract

OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with diverse associated risk factors and comorbidities. In this study, the authors sought to understand ADHD from a dimensional perspective and to identify neuroanatomical correlates of traits and behaviors that span diagnostic criteria. METHODS: Multimodal neuroimaging data and multi-informant cognitive and clinical data were collected in a densely phenotyped pediatric cohort (N=160; 70 with ADHD; age range, 9-12 years). Multivariate analysis identified associations between clinical and cognitive factors and multimodal neuroimaging markers (across tissue volume, cortical thickness, cortical area, and whi..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC


Awarded by NIMH


Funding Acknowledgements

This study was funded by project grant 1065895 from the National Health and Medical Research Council of Australia (NHMRC). The Children's Attention Project was funded by NHMRC project grant 1008522 and a grant from the Collier Foundation. The research was conducted within the Developmental Imaging research group, Murdoch Children's Research Institute and the Children's MRI Centre, Royal Children's Hospital, Melbourne. It was supported by the Murdoch Children's Research Institute, the Royal Children's Hospital, the Royal Children's Hospital Foundation, the Department of Paediatrics at the University of Melbourne, and the Victorian Government's Operational Infrastructure Support Program. The authors also thank Dr. Michael P. Milham and the ADHD-200 consortium for making the ADHD-200 data set available to researchers. Funding for the NYU cohort was provided by NIMH (R01MH083246), Autism Speaks, the Stavros Niarchos Foundation, the Leon Levy Foundation, and an endowment provided by Phyllis Green and Randolph Cowen.Dr. Sciberras is supported by an NHMRC Career Development Fellowship (1110688). Dr. Anderson was supported by an NHMRC Senior Practitioner Fellowship (1079478). Dr. Nicholson was funded by the Australian Communities Foundation through the Roberta Holmes Chair for the Transition to Contemporary Parenthood Program (Coronella subfund). Dr. Efron is supported by a Clinical Scientist Fellowship from the Murdoch Children's Research Institute.