Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): matching 'liquid biopsy' and quantitative tumor modeling
Sweet Ping Ng, Houda Bahig, Jihong Wang, Carlos E Cardenas, Anthony Lucci, Carolyn S Hall, Salyna Meas, Vanessa N Sarli, Ying Yuan, Diana L Urbauer, Yao Ding, Shane Ikner, Dinh Vi, Baher A Elgohari, Jason M Johnson, Heath D Skinner, G Brandon Gunn, Adam S Garden, Jack Phan, David I Rosenthal Show all
BMC CANCER | BMC | Published : 2018
BACKGROUND: Magnetic resonance imaging (MRI) has improved capacity to visualize tumor and soft tissue involvement in head and neck cancers. Using advanced MRI, we can interrogate cell density using diffusion weighted imaging, a quantitative imaging that can be used during radiotherapy, when diffuse inflammatory reaction precludes PET imaging, and can assist with target delineation as well. Correlation of circulating tumor cells (CTCs) measurements with 3D quantitative tumor characterization could potentially allow selective, patient-specific response-adapted escalation or de-escalation of local therapy, and improve the therapeutic ratio, curing the greatest number of patients with the least ..View full abstract
The 'liquid biopsy' component of the study is funded by the Radiological Society of North American Fellow Grant, the Mike Hogg Fund, and the Royal Australian and New Zealand College of Radiologists Research Grant.