Estimating the impact of structural directionality: How reliable are undirected connectomes?
Penelope Kale, Andrew Zalesky, Leonardo L Gollo
Network Neuroscience | MIT PRESS | Published : 2018
Directionality is a fundamental feature of network connections. Most structural brain networks are intrinsically directed because of the nature of chemical synapses, which comprise most neuronal connections. Because of the limitations of noninvasive imaging techniques, the directionality of connections between structurally connected regions of the human brain cannot be confirmed. Hence, connections are represented as undirected, and it is still unknown how this lack of directionality affects brain network topology. Using six directed brain networks from different species and parcellations (cat, mouse, C. elegans, and three macaque networks), we estimate the inaccuracies in network measures (..View full abstract
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Awarded by National Health and Medical Research Council
Leonardo L. Gollo, National Health and Medical Research Council (http://dx.doi.org/10.13039/501100000925), Award ID: APP1110975. Andrew Zalesky, National Health and Medical Research Council (http://dx.doi.org/10.13039/501100000925), Award ID: APP1047648.