Predicting the Outcomes of New Short-Course Regimens for Multidrug-Resistant Tuberculosis Using Intrahost and Pharmacokinetic-Pharmacodynamic Modeling
Tan N Doan, Pengxing Cao, Theophilus I Emeto, James M Mccaw, Emma S McBryde
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | AMER SOC MICROBIOLOGY | Published : 2018
Short-course regimens for multidrug-resistant tuberculosis (MDR-TB) are urgently needed. Limited data suggest that the new drug bedaquiline (BDQ) may have the potential to shorten MDR-TB treatment to less than 6 months when used in conjunction with standard anti-TB drugs. However, the feasibility of BDQ in shortening MDR-TB treatment duration remains to be established. Mathematical modeling provides a platform to investigate different treatment regimens and predict their efficacy. We developed a mathematical model to capture the immune response to TB inside a human host environment. This model was then combined with a pharmacokinetic-pharmacodynamic model to simulate various short-course BDQ..View full abstract
Awarded by Early Career Researcher Grant from the University of Melbourne
We gratefully acknowledge the financial support provided by a PRISM2 Seed Funding Grant from the Australian Government National Health and Medical Research Council Centre of Research Excellence in Infectious Diseases Modelling to Inform Public Health Policy (granted to T.N.D. and P.C.) and an Early Career Researcher Grant from the University of Melbourne (grant number 1655271, granted to T.N.D.). The funders had no role in study design, data analysis and interpretation, or the decision to submit the work for publication. All authors declare that they have no competing interests.