Journal article

The relationship between habitual dietary sodium intake and RAAS blockade on circulating microparticle levels in type two diabetes

Sara Baqar, Dorothy Liu, Lisa F Lincz, Yee Wen Kong, George Jerums, Elif I Ekinci

CLINICAL SCIENCE | PORTLAND PRESS LTD | Published : 2018

Abstract

OBJECTIVE: Low sodium intake is paradoxically associated with adverse cardiovascular outcomes in individuals with type 2 diabetes mellitus (T2D), possibly from renin-angiotensin-aldosterone system (RAAS) activation, leading to endothelial dysfunction. In the present study, we investigated the associations between habitual sodium intake and RAAS blockade on endothelial function by measuring circulating microparticles (MPs) in individuals with T2D. METHODS: We conducted a prospective, cross-sectional study in 74 individuals with T2D. Habitual dietary sodium intake was estimated by using the mean of three corrected 24-h urine sodium excretion measurements (24hUNa). MP subtypes in platelet-free ..

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Grants

Awarded by NHMRC Early Career Research Fellowship


Awarded by National Heart Foundation Health Professional Scholarship


Funding Acknowledgements

This work was supported by the NHMRC Early Career Research Fellowship [grant number #1054312 (to E.I.E.)]; the Viertel Clinical Investigatorship (to E.I.E.); Sir Edward Weary Dunlop Medical Research Foundation grant (to E.I.E.); the RACP Fellowship (to E.I.E.); and the National Heart Foundation Health Professional Scholarship [grant number 100287 (to S.B.)].