Journal article

Curcumin and its Allied Analogues: Epigenetic and Health Perspectives - a Review

Muhammad Imran, Muhammad Nadeem, Muhammad Asif Khan, Sheraz Ahmed, Ali Imran, Rai Muhammad Amir, Muhammad Umair Arshad, Syed Amir Gilani, Farhan Saeed, Abdur Rauf, Zaffar Mehmood, Shaista Khan, Hafiz Ansar Rasul Suleria

Czech Journal of Food Sciences | CZECH ACADEMY AGRICULTURAL SCIENCES | Published : 2017

Abstract

Curcumin (diferuoyl methane) is a yellow active ingredient present in turmeric. It is a homodimer of feruloylmethane that comprises a hydroxyl and methoxy group (heptadiene with two Michael acceptors), and α-, β-diketone. It contains various metabolites, i.e. hexahydrocurcumin (HHC), tetrahydrocurcumin (THC), octahydrocurcumin (OHC), dihydrocurcumin (DHC), curcumin sulphate, and curcumin glucuronide. Curcumin has been proven the most effective histone deacetylase (HDAC) inhibitor in HeLa nuclear extracts. It has the ability to affect the Akt, growth factors, NF-kB, and metastatic and angiogenic pathways. Curcumin has a strong therapeutic or preventive potential against several major human ai..

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University of Melbourne Researchers