Book Chapter

Clinical Interventions in HIV Cure Research

Thomas Aagaard Rasmussen, Ole S Sogaard

HIV VACCINES AND CURE: THE PATH TOWARDS FINDING AN EFFECTIVE CURE AND VACCINE | Advances in Experimental Medicine and Biology | SPRINGER INTERNATIONAL PUBLISHING AG | Published : 2018

Abstract

Research over the past decade has resulted in a much-improved understanding of how and where HIV persists in patients on otherwise suppressive antiretroviral therapy (ART). It has become clear that the establishment of a latent infection in long-lived cells is the key barrier to curing HIV or allowing for sustained ART-free remission. Informed by in vitro and ex vivo studies, several therapeutic approaches aimed at depleting the pool of latently infected cells have been tested in small-scale experimental clinical trials including studies of ART intensification, genome editing, ART during acute/early infection and latency reversal. Many studies have focused on the use of latency-reversing age..

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