Journal article
Acute metabolic and cardiovascular effects of mirabegron in healthy individuals
RKC Loh, MF Formosa, A La Gerche, AT Reutens, BA Kingwell, AL Carey
Diabetes Obesity and Metabolism | WILEY | Published : 2019
DOI: 10.1111/dom.13516
Abstract
Aims: To quantify acute energy expenditure, supraclavicular skin temperature and cardiovascular responses to four doses of the β3-adrenoceptor agonist, mirabegron. Materials and methods: A total of 17 individuals (11 men, six women) participated in this ascending-dose study, receiving single 50-, 100-, 150- and 200-mg doses of mirabegron on four separate days with 3 to 14 days wash-out between each dose. All variables were measured each visit from baseline to 180 minutes post mirabegron treatment. To determine brown adipose tissue (BAT) thermogenic efficacy at each dose, energy expenditure and supraclavicular skin temperature were compared from baseline to 180 minutes post mirabegron treatme..
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Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) of Australia and the Operational Infrastructure Support scheme of the Victorian State Government, Victoria, Australia. B.A.K. is a NHMRC Senior Principal Research Fellow. A.L.G. holds a NHMRC Career Development Fellowship and National Heart Foundation of Australia Future Leader Fellowship.