Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor

Adam L Valkovic; Miranda B Leckey; Alice R Whitehead; Mohammed A Hossain; Asuka Inoue; Martina Kocan; Ross AD Bathgate

Journal article

Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor

Adam L Valkovic, Miranda B Leckey, Alice R Whitehead, Mohammed A Hossain, Asuka Inoue, Martina Kocan, Ross AD Bathgate

Pharmacology Research & Perspectives | JOHN WILEY & SONS LTD | Published : 2018

DOI: 10.1002/prp2.432

University of Melbourne Researchers

Akhter Hossain Author Florey Department of Neuroscience and Mental Health

Ross Bathgate Author Florey Department of Neuroscience and Mental Health

Martina Kocan Author Florey Department of Neuroscience and Mental Health

Related Projects (2)

Determining modes of binding and activation of complex G-protein coupled receptor targets

The peptide hormones relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as..

UNRAVELLING THE BINDING AND ACTIVATION MECHANISM OF A COMPLEX G PROTEIN-COUPLED RECEPTOR

The peptide hormone relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as ..

Grants

Awarded by Japan Agency for Medical Research and Development

Awarded by Japan Society for the Promotion of Science

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Japan Agency for Medical Research and Development, Grant/Award Number: JP17gm5910013; Japan Society for the Promotion of Science, Grant/Award Number: 17K08264; National Health and Medical Research Council, Grant/Award Number: 1043750, 1100676; Victorian Government Operational Infrastructure Support Program