Journal article

A thermodynamic framework for modelling membrane transporters

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal of Theoretical Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2019

Abstract

Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell membranes. Like all physical systems, the behaviour of membrane transporters is constrained by the laws of thermodynamics. However, many mathematical models of transporters, especially those incorporated into whole-cell models, are not thermodynamically consistent, leading to unrealistic behaviour. In this paper we use a physics-based modelling framework, in which the transfer of energy is explicitly accounted for, to develop thermodynamically consistent models of transporters. We then apply this methodology to model two specific transporters: the cardiac sarcoplasm..

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Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by Australian Research Council


Awarded by Heart Foundation of New Zealand


Awarded by Marsden Fund Council by Royal Society Te Aparangi


Funding Acknowledgements

M.P. thanks Dr. Daniel Hurley for his assistance in setting up a reference environment for this paper. This research was in part conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036), and the Australian Research Council's Discovery Projects funding scheme (project DP170101358). M.P. would like to acknowledge financial support provided by an Australian Government Research Training Program Scholarship. P.J.G. would like to thank the Melbourne School of Engineering for its support via a Professorial Fellowship. K.T. is supported by the Heart Foundation of New Zealand (Research Fellowship 1692) and the Marsden Fund Council from Government funding, managed by Royal Society Te Aparangi (Marsden Fast -Start UOA1703).