Journal article
meaRtools: An R package for the analysis of neuronal networks recorded on microelectrode arrays
S Gelfman, Q Wang, YF Lu, D Hall, CD Bostick, R Dhindsa, M Halvorsen, KM McSweeney, E Cotterill, T Edinburgh, MA Beaumont, WN Frankel, S Petrovski, AS Allen, MJ Boland, DB Goldstein, SJ Eglen
Plos Computational Biology | PUBLIC LIBRARY SCIENCE | Published : 2018
Abstract
Here we present an open-source R package ‘meaRtools’ that provides a platform for analyzing neuronal networks recorded on Microelectrode Arrays (MEAs). Cultured neuronal networks monitored with MEAs are now being widely used to characterize in vitro models of neurological disorders and to evaluate pharmaceutical compounds. meaRtools provides core algorithms for MEA spike train analysis, feature extraction, statistical analysis and plotting of multiple MEA recordings with multiple genotypes and treatments. meaRtools functionality covers novel solutions for spike train analysis, including algorithms to assess electrode cross-correlation using the spike train tiling coefficient (STTC), mutual i..
View full abstractGrants
Awarded by Wellcome Trust
Funding Acknowledgements
RD was supported by the NIH training grant T32 GM007367, EC was supported by the Wellcome Trust, WNF was supported by funding from NIH R01 NS091118, MJB and DBG were supported by the CURE AHC and the Robbins Family Gift. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.