Journal article

Impairment of Liver Glycogen Storage in the db/db Animal Model of Type 2 Diabetes: A Potential Target for Future Therapeutics?

Mitchell A Sullivan, Brooke E Harcourt, Ping Xu, Josephine M Forbes, Robert G Gilbert

CURRENT DRUG TARGETS | BENTHAM SCIENCE PUBL LTD | Published : 2015

Abstract

After the discovery of the db gene in 1966, it was determined that a blood-borne satiety factor was produced excessively, but was not responded to, in db/db mice. This model for type 2 diabetes is widely used since it phenocopies human disease and its co-morbidities including obesity, progressive deterioration in glucose tolerance, hypertension and hyperlipidaemia. Db/db mice, unlike their non-diabetic controls, have consistently elevated levels of liver glycogen, most likely due to hyperphagia. In transmission electron micrographs, liver glycogen usually shows a composite cauliflower-like morphology of large "α particles" (with a wide range of sizes) made up of smaller "β particles" bound t..

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Grants

Awarded by Chinese National Basic Research Programs


Awarded by National Natural Science Foundation of China


Awarded by International Collaboration Program


Awarded by NHMRC CJ Martin fellowship


Awarded by NHMRC Peter Doherty fellowship


Awarded by Australian Research Council


Funding Acknowledgements

This study was supported by the Chinese National Basic Research Programs (Grant No. 2011CB910600), the National Natural Science Foundation of China (Grant No. 31470809), the International Collaboration Program (Grant No. 2014DFB30020), an NHMRC CJ Martin fellowship (GNT1092451), and NHMRC Peter Doherty fellowship (GNT1072086), an Australian Research Council grant (DP130102461) and the 1000-Talents Program of the Chinese State Administration of Foreign Expert Affairs.