Circulating epinephrine is not required for chronic stress to enhance metastasis
Adam K Walker, Davide Martelli, Alexandra I Ziegler, Gavin W Lambert, Sarah E Phillips, Stephen J Hill, Robin M McAllen, Erica K Sloan
PSYCHONEUROENDOCRINOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
Signaling through β-adrenergic receptors drives cancer progression and β-blockers are being evaluated as a novel therapeutic strategy to prevent metastasis. Orthotopic mouse models of breast cancer show that β-adrenergic signaling induced by chronic stress accelerates metastasis, and that β2-adrenergic receptors on tumor cells are critical for this. Endogenous catecholamines are released during chronic stress: norepinephrine from the adrenal medulla and sympathetic nerves, and epinephrine from the adrenal medulla. β2-adrenergic receptors are much more sensitive to epinephrine than to norepinephrine. To determine if epinephrine is necessary in the effects of stress on cancer progression, we u..View full abstract
Awarded by National Breast Cancer Foundation Australia postdoctoral fellowship
Awarded by National Health and Medical Research Council
Awarded by NHMRC
This work was supported by a National Breast Cancer Foundation Australia postdoctoral fellowship (PF-15-014) and a Monash Interdisciplinary Research Scheme Award to AKW; the David and Lorelle Skewes Foundation, the Peter Mac Foundation, and the National Health and Medical Research Council (APP1147498, APP1098887). GL was supported by a Senior Research Fellowship from the NHMRC (APP1042492). This work was supported by the Victorian Government's Operational Infrastructure Support Program.